Ellen Pompeo - Craig De Cristo Photoshoot

Ellen Pompeo made her major studio screen debut in Brad Silberling's Moonlight Mile (2002), starring alongside Susan Sarandon, Dustin Hoffman and Jake Gyllenhaal. She received outstanding reviews for her portrayal of an outspoken young woman carrying a silent burden that's breaking her heart.

A native of Boston, Pompeo starred opposite Luke Wilson, Vince Vaughn and Will Ferrell in the wildly successful Old School (2003) and, before that, in Steven Spielberg's Catch Me If You Can (2002), opposite Leonardo DiCaprio.

Prior to Moonlight Mile (2002), Pompeo starred in several independent features, including In the Weeds (2000) and Coming Soon (1999), and she can also be seen in Life of the Party (2005).